23, 29, 37
Do not apply the guideline enolase threshold unmodified after ECPR. The authors' own conclusion is adopted by this book: prognostication algorithms should reflect the resuscitation method.
Favourable neurological survival at 180 days (29.3% against 21.7%, P = 0.191)
[VERIFICATION REQUIRED] - DOI/PMID not confirmed
Serial neuron-specific enolase, procalcitonin, C-reactive protein, neutrophil-to-lymphocyte ratio at 24-72 hours
Post-hoc sub-analysis, not powered for the biomarker comparison; contradicts the ECMO registry comparison on whether levels themselves differ. Structured abstract only. [VERIFICATION REQUIRED]
Enolase, C-reactive protein and the neutrophil-to-lymphocyte ratio did not differ between groups; procalcitonin was higher in ECPR (P below 0.01) and platelets, D-dimers and fibrinogen lower (P below 0.001). Enolase discriminated best in both groups - areas under the curve 0.89/0.90/0.91 conventionally against 0.78/0.90/0.90 in ECPR. Optimal cut-off points for both enolase and procalcitonin were higher in the ECPR group.
164 conventionally resuscitated against 92 ECPR patients from a randomised trial cohort