35, 33, 34
Avoid excessive negative inlet pressure and inflow restriction; the membrane lung is not a reliable microbubble filter.
With vs without dynamic bubble traps
DOI 10.1111/aor.13557; PMID 31408537
Static or dynamic inflow occlusion to generate microbubbles; oxygenator and dynamic bubble traps assessed for elimination.
In vitro, abstract only read, blood substitute.
Microbubble generation highly dependent on negative pressure at the inflow line; increasing speed and inflow restriction increased microbubbles; centrifugal pump identified as a main source; oxygenator's ability to withhold larger microbubbles limited; dynamic bubble traps significantly reduced count and gas volume.
In vitro venoarterial ECLS circuit with centrifugal pump, membrane oxygenator and occluder; 44% glycerin prime; 2500/3000/3400 rpm. Artif Organs 2020;44(3):268-277.