Good recovery after post-anoxic status epilepticus (Hofmeijer J) and the TTM2 continuous-electroencephalography substudy (Admiraal MM)

Certainty
Moderate
Chapters

23, 28, 51

Clinical implication

Post-anoxic status epilepticus is not, by itself, a prognostic sign. What carries the information is the background it arises from and what accompanies it. Treating status as automatically fatal is a self-fulfilling prophecy in miniature.

Comparator

Good neurological recovery

Design
Prospective cohort
Identifier

[VERIFICATION REQUIRED] - DOI/PMID not confirmed for either

Intervention

Characterisation of status epilepticus by onset time, background before onset, and accompanying poor-outcome markers

Limitations

Two separate sources combined in one row; withdrawal practice not excluded in either. Structured abstracts only. [VERIFICATION REQUIRED]

Link
Main result

In the pooled analysis, 8.8% recovered well overall, rising to 25% after excluding those with two or more established poor-outcome criteria; none of those who recovered had a suppressed or burst-suppression background before onset. In the substudy, status epilepticus occurred in 27% at a median of 42 hours; a favourable profile (late onset, continuous background, no poor-outcome markers) was present in 38%, of whom 60% survived and 40% had a good outcome - all patients lacking that profile had a poor outcome.

Population

274 patients with post-anoxic status epilepticus in the pooled analysis; 191 monitored patients in the trial substudy, of whom 52 developed status epilepticus

Verified
Year
2025