HEROES V-A: HEmoRrhagic cOmplications in veno-arterial Extracorporeal life Support: development and internal validation of a multivariable prediction model in adult patients (Willers A, Swol J, van Kuijk SMJ, Buscher H, McQuilten Z, Ten Cate H, Rycus PT, McKellar S, Lorusso R, Tonna JE)

36, 42, 45

Use individual risk factors rather than a score to inform anticoagulation intensity.

Internal validation

DOI 10.1111/aor.14340; PMID 35712783

Multivariable logistic prediction model for bleeding

Internal validation only; weak discrimination; no laboratory haemostasis variables; abstract only read.

29.0% bleeding complications. AUC 0.66. Predictors: sex, BMI, surgical cannulation, pre-ECLS respiratory and haemodynamic variables, pre-ECLS support and interventions, diagnosis. Authors: external validation warranted.

28,767 adults on V-A ECLS, ELSO Registry 2010-2020. Artif Organs 2022;46(11):2266-2283.