HEROES V-V - HEmorRhagic cOmplications in Veno-Venous Extracorporeal life Support: development and internal validation of multivariable prediction model in adult patients (Willers A, Swol J, van Kuijk SMJ, Buscher H, McQuilten Z, Ten Cate H, Rycus PT, McKellar S, Lorusso R, Tonna JE)

36, 42, 45

Registry-based bleeding prediction is only modestly better than chance; should not set anticoagulation intensity.

Internal validation

DOI 10.1111/aor.14148; PMID 34904241

Multivariable logistic prediction model for bleeding

Internal validation only; weak discrimination; no laboratory haemostasis variables; abstract only read.

3,933 (21.1%) bleeding complications. AUC 0.63. Predictors: pre-ECLS arrest, surgical cannulation, lactate, pO2, HCO3, ventilation rate, mean airway pressure, pre-ECLS CPB or RRT, pre-ECLS surgical interventions, diagnosis.

18,658 adults on V-V ECLS, ELSO Registry 2010-2020. Artif Organs 2022;46(5):932-952.