2, 25, 30, 46
Supports a critical delivery threshold that is a floor to stay above rather than a target to maximise, and undercuts the rationale for driving DO2 to supranormal levels. Do not apply the numeric threshold to an individual patient as a target.
Septic versus non-septic patients
DOI 10.1001/jama.1993.03510140084034; PMID 8411504
None - observational measurement of the DO2/VO2 relationship as delivery fell
Only 18 patients. Measured during withdrawal of life support - a low and falling metabolic state that does not represent an actively treated ICU patient. Population estimate with wide standard deviations; individual thresholds vary with temperature, sedation and disease.
Critical oxygen delivery identified from the biphasic DO2-VO2 relationship: 3.8 +/- 1.5 mL/min/kg in septic versus 4.5 +/- 1.3 mL/min/kg in non-septic patients, not significantly different. Critical and maximal oxygen extraction ratios also did not differ. Values considerably lower than previously reported.
18 critically ill adults in two tertiary ICUs: 9 septic, 9 non-septic, studied during discontinuation of life support