22
A survival benefit without a neurological benefit implies more survivors in poor neurological states. The source does not discuss this. Chapter 24 inherits it. The investigators also state that a randomised trial of temperature control in ECPR is under way.
Normothermic control, target 36 degrees
DOI 10.1161/circ.152.suppl_3.sun301
Hypothermic temperature control, target 32 to 34 degrees
Conference abstract; registry; the same analysis exists as a 2023 preprint with 949 patients and different point estimates (1.22 and 1.74) and neither report cross-references the other.
Survival at discharge 41.8% versus 27.0%. Favourable neurological outcome 19.6% versus 14.6%. Adjusted: hypothermia associated with in-hospital survival OR 1.67 (1.23 to 2.28) but NOT with favourable neurological outcome OR 1.16 (0.79 to 1.70). Less haemorrhage with hypothermia (7.9% versus 12.5%); no difference in cannulation-site bleeding or ischaemia.
926 of 2,157 SAVE-J II patients receiving temperature control after ICU admission; 555 hypothermic, 371 normothermic