23, 24
The second cohort to break the circularity, by a different method and with a 12-month endpoint. Confirms that two or more concordant findings, and repeated serial assessment, are what carry the weight - not any single test.
Modified Rankin Scale 4-6 at 12 months
NCT02231060; [VERIFICATION REQUIRED] - volume and DOI not confirmed
Multimodal markers within 14 days, with and without the Coma Recovery Scale-Revised
101 patients, no ECMO patients, excluding withdrawal deaths selects a cohort that is not the whole population. Structured abstract only. [VERIFICATION REQUIRED]
Poor outcome in 67.3%. Individual markers had high specificity, limited sensitivity and variable false-positive rates. Two or more unfavourable markers within 14 days produced no false positives, adjusted odds ratio 34.7. Adding the best Coma Recovery Scale score raised the area under the curve from 0.888 to 0.925.
101 adults comatose at 72 hours after cardiac arrest, eight German hospitals; patients undergoing withdrawal within four weeks were excluded