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The empirical fingerprint of the chapter's organising physiology: hypocapnia constricts while hypertension over-perfuses, and in ECPR both are set by the same person within the same two minutes.
Minimal change in either
DOI 10.1097/pcc.0000000000003216
Relative carbon dioxide fall over 30%, and relative mean arterial pressure rise over 50%, after ECMO initiation
Paediatric, all-indication registry; the interaction term sits exactly at the conventional threshold; confounding by severity is unaddressed.
Neurological complications 15.6%. Carbon dioxide fall over 30%: adjusted OR 1.25 (1.07 to 1.46), P = 0.005. Pressure rise over 50%: 16.9% versus 13.1%, P = 0.007. Within the large-carbon-dioxide-fall group the effect of rising pressure was additive, 0.05% per blood pressure percentile (0.001 to 0.11), P = 0.05.
7,270 paediatric ECMO runs, all indications and modes, 2010 to 2019