1, 19, 20, 23
Standard resuscitation on scene
Invasive bundle: intra-arrest transport, ECPR if no ROSC within 60 minutes, immediate invasive assessment and treatment
Stopped for futility at a prespecified interim analysis. Tests a whole bundle rather than ECPR alone; single high-performing system.
Refractory out-of-hospital cardiac arrest of presumed cardiac cause
Survival with CPC 1-2 at 180 days
31.5% vs 22.0%; absolute difference 9.5% (95% CI -1.3 to 20.1), p=0.09
It cannot attribute any of the observed difference specifically to the extracorporeal circuit rather than to intra-arrest transport or immediate invasive assessment.
An invasive intra-arrest bundle including ECPR produced a directionally favourable but statistically non-significant improvement in 180-day neurologically favourable survival.