Chapters 47–52. The circuit is a second compartment — with its own volume of distribution, adsorption and clearance.
# | Chapter | Core question it answers |
47 | Pharmacokinetic Changes During ECMO | Which drug properties predict sequestration? |
48 | Antimicrobial Dosing During ECMO | Am I under-dosing the antibiotic that matters? |
49 | Sedatives and Analgesics | Why does the dose keep escalating? |
50 | Cardiovascular Drugs | Vasopressors and inotropes under continuous flow. |
51 | Antiepileptic and Other Critical Care Drugs | Where therapeutic drug monitoring is mandatory. |
52 | ECMO + CRRT Pharmacokinetics | Two circuits, two clearances — how do I dose? |