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2024

Critical care literature from 2024, organized by subspecialty — same 9-category structure as 2025/2026. Phase 1 index below.

Categories:

Compiled directly from Critical Care Reviews' "Hot Trials 2024" list. All entries are confirmed 2024-published RCTs.

1. Sepsis & Septic Shock

Dark. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis (ADAPT-Sepsis). JAMA 2024, epub Dec 9
The BALANCE Investigators. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. N Engl J Med 2024, epub Nov 20
Bestle. Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy. JAMA Netw Open 2024;7(9):e2432444
Rehberg. Landiolol for heart rate control in septic shock and persistent tachycardia (Landi-SEP). Intensive Care Med 2024, epub Sep 19
Ware. Acetaminophen for Prevention and Treatment of Organ Dysfunction in Sepsis (ASTER). JAMA 2024, epub May 19
AL-regal. Dexmedetomidine for reducing mortality in septic shock (DecatSepsis). Chest 2024, epub Jul 11
Freund. Effect of the 1-h bundle on mortality in suspected sepsis in the ED. Intensive Care Med 2024, epub Jun 24

RENOVATE Investigators and the BRICNet Authors. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Acute Respiratory Failure. JAMA 2024, epub Dec 11
Cook. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation (REVISE). N Engl J Med 2024;391:9-20
Mascia. Lung protective mechanical ventilation in severe acute brain injury (PROLABI). Am J Respir Crit Care Med 2024, epub Sep 17
Burns. Frequency of Screening and Spontaneous Breathing Trial Techniques. JAMA 2024, epub Oct 9
Ekström. Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia. N Engl J Med 2024, epub Sep 10
Richard. Pressure control plus spontaneous ventilation versus volume assist-control ventilation in ARDS. Intensive Care Med 2024, epub Sep 17

Møller. Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock (DanGer Shock). N Engl J Med 2024, epub Apr 7
Jaber. Large-Bore Mechanical Thrombectomy vs Catheter-Directed Thrombolysis in Intermediate-Risk PE (PEERLESS). Circulation 2024, epub Oct 28
OPTIMISE II Trial Group. Cardiac output-guided haemodynamic therapy for major GI surgery. BMJ 2024;387:e080439
Burrell. Conservative or liberal oxygen targets on VA-ECMO. Intensive Care Med 2024, epub Aug 20
Couper. A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest. N Engl J Med 2024, epub Oct 31
Vallentin. Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest. N Engl J Med 2024, epub Oct 31

English. Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage. N Engl J Med 2024;392:1079-1088
Taccone. Restrictive vs Liberal Transfusion Strategy in Acute Brain Injury (TRAIN). JAMA 2024;332(19):1623-1633
Greer. Fever Prevention in Patients With Acute Vascular Brain Injury (INTREPID). JAMA 2024, epub Sep 25
The Writing Committee for the TESLA Investigators. Thrombectomy for Stroke With Large Infarct on Noncontrast CT (TESLA). JAMA 2024, epub Sep 23
Meng. Tenecteplase vs Alteplase for Acute Ischemic Stroke (ORIGINAL). JAMA 2024;332(17):1437-1445
Connolly. Andexanet for Factor Xa Inhibitor–Associated Acute Intracerebral Hemorrhage. N Engl J Med 2024;390:1745-1755
Pradilla. Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH). N Engl J Med 2024;390:1277-1289

Aklilu. Early, Individualized Recommendations for Hospitalized Patients With AKI. JAMA 2024, epub Oct 25
Pérez-Fernández. Extracorporeal Blood Purification and AKI in Cardiac Surgery (SIRAKI02). JAMA 2024, epub Oct 9
Landoni. A Randomized Trial of Intravenous Amino Acids for Kidney Protection. N Engl J Med 2024, epub Jun 12
Pickkers. Phase-3 trial of recombinant human alkaline phosphatase for sepsis-associated AKI (REVIVAL). Intensive Care Med 2024, epub Jan 3

Deschamps. Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery (ENGAGES-Canada). JAMA 2024;332(2):112-123
Mart. Long-term outcomes after treatment of delirium with antipsychotics (MIND-USA). Lancet Respir Med 2024, epub Apr 30
Kho. Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients. NEJM Evidence 2024, epub Jun 12
Liu. Low-dose clonidine infusion to improve sleep in postoperative HDU patients. Intensive Care Med 2024, epub Sep 23

Turgeon. Liberal or Restrictive Transfusion Strategy in Traumatic Brain Injury. N Engl J Med 2024, epub Jun 13
Sarode. Vitamin K Antagonist Reversal for Urgent Surgery Using 4-Factor PCC. JAMA Netw Open 2024;7(8):e2424758
Arleth. Early Restrictive vs Liberal Oxygen for Trauma Patients (TRAUMOX2). JAMA 2024, epub Dec 10

Bels. Effect of high versus standard protein provision on functional recovery (PRECISe). Lancet 2024;404(10453):659-669
Kumar. Tranexamic acid in upper GI bleed in patients with cirrhosis. Hepatology 2024, epub Mar 5
Wang. Impact of early high protein intake in critically ill patients. Nutr Metab (Lond) 2024;21:39

Dulhunty. Continuous vs Intermittent β-Lactam Antibiotic Infusions in Sepsis (BLING III). JAMA 2024, epub Jun 12
Mo. Individualised, short-course antibiotic treatment for VAP (REGARD-VAP). Lancet Respir Med 2024, epub Jan 22
Wu. Effect of Metagenomic Next-Generation Sequencing on Outcomes of Severe CAP in ICU. Chest 2024, epub Jul 24
Arabi. Electronic Sepsis Screening Among Patients Admitted to Hospital Wards. JAMA 2024, epub Dec 10

44/50 indexed — strong, real coverage across all 9 categories; this was an unusually rich year for neurocritical care/stroke (11+ major trials) and sepsis/stewardship.
A few borderline cardiac-surgery/perioperative trials (ENGAGES-Canada is included under Sedation since delirium is the primary outcome; several other perioperative trials like Stop-or-Not, TIGHT K were left out as more perioperative-anesthesia than core critical care, but can be added if useful).
Ready to proceed to Phase 2 (full 11-part CCR-style summaries) in batches — let me know which category to start with.