Four major 2026 hemodynamics/fluid resuscitation studies, summarized in full CCR 11-part format. Note: the Prescott study is a large observational (target-trial-emulation-style) cohort study rather than an RCT — flagged accordingly in its Design & Methods section.
Verdict | Trial | Journal | Takeaway |
⚪ | NEJM | Restricted-fluid/early-vasopressor vs fluid-forward in ED septic shock: DAOH90 identical. | |
🔴 | NEJM | Elective LV unloading (Impella) in high-risk PCI: no benefit, excess CV mortality (HR 1.91). | |
🟡 | NEJM | Catheter-directed fibrinolysis for PE: composite improved, but driven by decompensation not death. | |
🟢 | JAMA Netw Open | ≥30 mL/kg fluid associated with lower mortality in septic hypoperfusion. |